Welcome to my home page! I am an analytical chemist with a strong interest in (bio)sensor and Lab-on-a-chip applications. At the present time I am working as head of R&D at the Implen GmbH in Munich. Previously, I was a senior scientist and project manager at the Beckman Coulter Biomedical GmbH (BCB), Olympus Life Science Research Europe GmbH (OLRE) and Advalytix AG.
From August 2000 until November 2001 I was a post-doc researcher at the Institute of Applied Physics (Prof. Bo Liedberg) in Linköping, Sweden. I have reached my Dr. rer nat (PhD) degree at the Institute of Analytical Chemistry, Chemo- and Biosensors (Prof. Otto S. Wolfbeis), University of Regensburg, Germany. During university time the focus of my research was the investigation of new electrochemical and optical (bio)sensors, phase-aggregation of mixed monolayers and the preparation of molecular gradients.
Research (University of Regensburg, April 1996 to July 2000)
- stability of alkanethiols on metal sufaces, especially gold
- synthesis of w-functionalized alkanethiols
- capacitive detection in ultrathin chemo- and biosensors (for example HSA, LDL, bacteriophages)
- electrically addressable immobilization
- non-linear impediometric detection in chemo- and biosensors
Publications
1. Michael Riepl (1997). Immobilization of Proteins on w-Functionalized Alkylthiol Layers, and Development of a Capacitive Immunosensor. Diploma thesis, University of Regensburg.
2. Vladimir M. Mirsky, Michael Riepl and Otto S. Wolfbeis (1997). Capacitive monitoring of protein immobilization and antigen-antibody reactions on monomolecular alkylthiol films on gold electrodes. Biosensors & Bioelectronics 12, 977-989.
3. Bajari T. M., Lindstedt K. A., Riepl M., Mirsky V. M., Nimpf J., Wolfbeis O. S., Dresel H. A., Bautz E. K. F., Schneider W. J. (1998). A minimal Binding Domain of the Low Density Lipoprotein Receptor Gene Family. Biol. Chem. 379, 1053-1062.
4. Vladimir M. Mirsky, Michael Riepl, Markus Mass, Thomas Hirsch, Ruediger Schweiss, Otto S. Wolfbeis (1999). Capacitive Detection of Analyte Binding in Thin Film Chemo- and Biosensors. In Solid State Chemical and Biochemical Sensors, 9th Cimtec-World Forum on New Materials 441-448, ed. P. Vincenzini, L. Dori, Techna Srl. Faenza, Italy.
5. Michael Riepl, Vladimir M. Mirsky and Otto S. Wolfbeis (1999). Electrical control of alkanethiols self-assembly on the gold surface as an approach for preparation of microelectrode arrays. Mikrochim. Acta131, 29-34.
6. Vladimir M. Mirsky, Michael Riepl, Christian Krause, Ivan Novotny, Markus Splonskowski, Vlastimil Rehacek, Vladimir Tvarozek, Helmut Hummel, Otto S. Wolfbeis (1998). Thin film electrodes for capacitive chemo- and biosensors: an optimization of the electrodes geometry. In Trends and New Applications of Thin Films, Materials Science Forum287-288, 423-426, ed. H. Hoffmann, Trans Tech Publications Ltd, Switzerland.
7. V. Rehacek, I. Novotny, V. Tvarozek, M. Riepl, T. Hirsch, M. Mass, R. Schweiss, V.M. Mirsky & O.S. Wolfbeis (1998). Capacitive Detection in Thin Film Sensors and Biosensors. In Proc. ASDAM ´98 (Intl. Conf. Adv. Semiconductor Devices & Microsystems) publ. by IEEE (Piscataway, NJ), Smolenice, Slovakia.
8. Nadia Wrobel, Michael Riepl, Manfred Schinkinger, Vladimir M. Mirsky, Otto S. Wolfbeis (1999). Capacitive thin film biosensors for bacteriophages and nucleic acids. Proceedings of the European Medical & Biological Engineering Conference, EMBEC ´99, 362-363.
9. Michael Riepl, Vladimir M. Mirsky, Ivan Novotny, Vladimir Tvarozek, Vastimil Rehacek, Otto S. Wolfbeis (1999). Optimization of capacitive affinity sensors: drift supression and signal amplification. Anal. Chim. Acta 392, 77-84.
10. Vladimir M. Mirsky, Nadia Wrobel, Michael Riepl, Thomas Hirsch, Otto S. Wolfbeis (1999). Intelligente Nanostrukturen für Biosensoren und Sensoren-Arrays. BioTec 4, 28-32.
11. Michael Riepl (2000). New capacitive (bio)sensors based on self-assembled monolayers on gold and palladium. PhD thesis, Regensburg, Germany
12. Michael Riepl, Ingemar Lundström and Bo Liedberg (2001). New methods for the preparation of (bio)sensor surfaces: Molecular gradients and mixed monolayers containing oligo(ethylene glycols). Proceedings 2. Biosensor-Symposium, Tübingen, Germany.
13. Michael Riepl, Karin Enander, Bo Liedberg, Michael Schäferling, M. Kruschina, Flavio Ortigao (2002). Functionalized Surfaces of Mixed Alkanethiols on Gold as a Platform for Oligonucleotide Microarrays. Langmuir 18,7016-7023.
14. Michael Schäferling, Michael Riepl, Petra Pavlickova, Hubert Paul, Dev Kambhampati, Bo Liedberg (2003) Functionalized Self-Assembled Monolayers on Gold as Binding Matrices for the Screening of Antibody-Antigen Interactions. Microchim. Acta142 (4), 193-204.
15. Michael Riepl, Mattias Östblom, Ingemar Lundström, Stefan C.T. Svensson, Arnoud W. Denier van der Gon, Michael Schäferling and Bo Liedberg (2005). Molecular Gradients: An Efficient Approach to Optimize the Surface Properties of Biomaterials and BioChips. Langmuir21, 1042-1050.
16. Michael Schäferling, Michael Riepl and Bo Liedberg (2009). Self-Assembled Monolayers with Molecular Gradients: A New Tool for Optimizing Surface Properties of Biosensors. Springer book "Combinatorial methodologies for development of chemical and biological sensors", Potyrailo R.A., Mirsky V.M. (Eds). ISBN: 978-0-387-73712-6
Posters and oral presentations
1. Vladimir M. Mirsky, Christian Krause, Michael Riepl and Otto Wolfbeis (1996). Applications of detection for chemical sensors and biosensors based on organized organic films. Luckenwalde, Germany.
2. Michael Riepl (1996). Review about capacitive measurements. Copernicus project meeting 15-20 Oct, Athens, Greece.
3. Vladimir M. Mirsky, Michael Riepl und Otto S. Wolfbeis (1997). Verfolgung der Proteinimmobilisation und Antigen-Antikörper-Reaktionen auf monomolekularen Alkylthiolschichten auf Goldelektroden mittels kapazitiver Messungen. ANAKON April 06-09, Konstanz, Germany.
4. M. Riepl, M. Mass, V. M. Mirsky, T. M. Bajari, H. A. Dresel, E. F. K. Bautz, V. Tvarozek, I. Novotny, V. Rehacek, W. J. Schneider and O. S. Wolfbeis (1997). Capacitive Detection of Biomolecules. ABI Summerschool, September 07-10, Neuchatel, Switzerland.
5. Michael Riepl (1997). Capacitive detection of (bio)molecules by chemical sensors and biosensors based on self-assembled alkylthiol monolayers. Giulio Milazzo School on Bioelectrochemistry, September 12-19, Szeged, Hungary.
6. Vladimir M. Mirsky, Michael Riepl, Christian Krause, Ivan Novotny, Markus Splonskowski, Vastimil Rehacek, Vladimir Tvarozek, Helmut Hummel, Otto S. Wolfbeis (1998). Thin film electrodes for capacitive chemo- and biosensors: An optimization of the electrode geometry. TATF, March 18-20, Regensburg, Germany.
7. V. M. Mirsky, M. Riepl, M. Mass, T. Hirsch, O. S. Wolfbeis (1998). Capacitive Binding Detection in Thin Film Biosensors. Biosensors, June 03-05, Berlin, Germany.
8. Michael Riepl, Vladimir M. Mirsky, Otto S. Wolfbeis (1998). Electrically Addressable Immobilization of Thiols on Arrays of Gold Electrodes. ESF conference: Reactivity in organized microstructures, July 18-23, Wiesbaden-Naurod, Germany.
9. Michael Riepl, Vladimir M. Mirsky, Otto S. Wolfbeis (1998). Capacitive Affinity Biosensors Based on w-Modified Alkanethiols. EUROANALYSIS X, September 06-11, Basel, Switzerland.
10. Nadia Wrobel, Michael Riepl, Vladimir M. Mirsky, Otto S. Wolfbeis (1998). Capacitive Biosensors: Signal Amplification and Preparation of Sensor Arrays. ABI Summerschool, September 02-04, Neuchatel, Switzerland.
11. Riepl M., Mirsky V. M., Wolfbeis O. S. (1999). Unterdrückung der Signaldrift bei Affinitätssensoren. Biosensor-Symposium, April 14-16, Munich, Germany.
12.Wrobel N., Riepl M., Mirsky V. M., Wolfbeis O. S. (1999). Vergleich verschiedener Immobilisierungsmethoden von DNA auf Goldoberflächen. Biosensor-Symposium, April 14-16, Munich, Germany.
13. Nadia Wrobel, Michael Riepl, Manfred Schinkinger, Vladimir M. Mirsky, Otto S. Wolfbeis (1999). Capacitive thin film biosensors. EMBEC´99, November 04-07, Wien, Austria.
14. Michael Riepl (2000). New capacitive (bio)sensors based on self-assembled monolayers of thiols on gold and palladium electrodes (Invited talk). May 12, Linköping University, Sweden.
15. Michael Riepl, Ingemar Lundström, Bo Liedberg (2001). Gradienten und Phase-Aggregation von Thiolen auf Gold. Neue Methoden zum Herstellen von Sensoroberflächen. 2. Biosensor-Symposium, April 01-03, Tübingen, Germany.
16. V.M. Mirsky, M. Riepl, M. Östblom, B. Liedberg (2002). Self-assembled monolayers of alkylthiols on palladium electrodes, Electrochemistry in Microscopic and Molecular Dimensions, September 15.-20., ISE Düsseldorf, Germany
17. Michael Riepl (2008). Molecular analysis on microstructured glass slides: new aspects for PCR. Oral presentation at Lab-on-a-Chip World Congress, May 07, Barcelona, Spain.
18. Rene Pflugradt, Sabine Lutz-Bonengel, Michael Riepl, Wolfgang Mann and Marianna Alunni-Fabbroni (2008). AmpliGrid for the analysis of low copy number samples and single cells: Applications in Forensic Science, Lab-on-a-Chip World Congress, May 07.-08., Barcelona, Spain.
19. Karin Görner, Michael Riepl and Marianna Alunni-Fabbroni (2008). Ampligrid and Amplicell: Novel platforms for cell-based PCR analysis, Lab-on-a-Chip World Congress, May 07.-08., Barcelona, Spain.
20. Karin Görner, Michael Riepl and Marianna Alunni-Fabbroni (2008). AmpliCell: A novel cell culture and PCR platform based on the AmpliGrid technology, 33rd FEBS Congress, June 28.-July 03., Athens, Greece.
21. Michael Riepl (2009). From SAW to 1 µL PCR: Applications for lab-on-a-surface. Oral presentation at 6. Deutsches Biosensor Symposium, March 29.-April 01., Freiburg, Germany.
22. Michael Riepl (2009). Scientific career in the healthcare business area diagnostics. Oral presentation at "CENS meets industry", July 10, Munich, Germany.
If you have any comments, suggestions, or questions please drop me a line. I would be happy to receive your e-mail. My e-mail address: mr
M. Riepl, University of Linköping, Institute of Applied Physics or University of Regensburg, Institute of Analytical Chemistry, Chemo- and Biosensors, Advalytix and Implen shall not be responsible for or liable in respect of errors or omissions from these WWW pages.
Welcome to my home page! I am an analytical chemist with a strong interest in (bio)sensor and Lab-on-a-chip applications. At the present time I am working as head of R&D at the